Below is a list of the observed CityU holidays for the 2021/22 Academic year. City University of Seattle does not officially observe any holidays other than those listed. City University of Seattle administrative offices and classrooms will be closed on the dates listed in the above table.
| Canadian Holiday | Date | US Holiday | Date | |
| 1 | Canada Day, National | Thursday, July 1, 2021 | Independence Day Observed | Monday, July 5, 2021 |
| 2 | Civic Holiday, BC/AB | Monday, August 2, 2021 | Labor Day | Monday, September 6, 2021 |
| 3 | Labour Day, National | Monday, September 6, 2021 | Veterans Day | Thursday, November 11, 2021 |
| 4 | Thanksgiving Day, BC/AB | Monday, October 11, 2021 | Thanksgiving Break | Thursday, November 25, 2021 |
| 5 | Remembrance Day, BC/AB | Friday, November 11, 2021 | Thanksgiving Break | Friday, November 26, 2021 |
| 6 | Christmas Eve Observed | Friday, December 24, 2021 | Christmas Eve Observed | Friday, December 24, 2021 |
| 7 | New Year’s Day Observed | Monday, January 3, 2022 | New Year’s Day Observed | Monday, January 3, 2022 |
| 8 | Family Day, BC/AB | Monday, February 21, 2022 | MLK Day | Monday, January 17, 2022 |
| 9 | Good Friday, BC/AB | Friday, April 15, 2022 | President’s Day | Monday, February 21, 2022 |
| 10 | Victoria Day, Canada | Monday, May 23, 2022 | Memorial Day | Monday, May 30, 2022 |